임플랜트 주위 연조직세포의 세포-기질 접착
CELL-MATRIX ADHESIONS OF SOFT TISSUE CELLS AROUND DENTAL IMPLANTS
이석원, 이재봉, 류인철, 한종현,
소속 상세정보
이석원 ( Lee Suk-Won ) - 가톨릭대학교 의과대학 치과학교실 성빈센트병원 치과
이재봉 ( Lee Jai-Bong ) - 서울대학교 치과대학 치과보철학교실
류인철 ( Rhyu In-Chul ) - 서울대학교 치과대학 치주과학교실
한종현 ( Han Chong-Hyun ) - 연세대학교 치과대학 치과보철학교실
KMID : 0362420060440010073
Abstract
The importance of soft tissue response to implant abutments has become one of the major issues in current implant dentistry. To date, numerous studies have emphasized on maintaining connective tissue barriers in quantity, as well as in quality fir the long term success of dental implants. The cells mainly consisting the soft tissue around dental implants are fibroblasts and epithelial cells. The mechanism of the fibroblasts adhesions to certain substrata can be explained by the ’’focal adhesion’’ theory. On the other hand, epithelial cells adhere tn the substratum via hemidesmosomes. The typical integrin-mediated adhesions of cells to certain matrix are called ’’cell-matrix adhsions’’. The focal adhesion complex of fibroblasts, in relation to the cell-matrix adhsions, consists of the extracellular matrix(ECM) such as fibronectin, the transmembrane proteins such as integrins, the intracellular cytoplasmic proteins such as vinculin, talin, and more, and the cytoskeletal structures such as filamentous actin and microtubules. The mechanosensory function of integrins and focal adhesion complexes are considered to play a major role in the cells adhesion, migration, proliferation, differentiation, division, and even apoptosis. The ’’3-D matrix adhesions’’ defined by Cukierman et al. makes a promising future for the verification of the actual process of the cell-matrix adhesions in vivo and can be applied to the field of implant dentistry in relation to obtaining strong soft tissue attachment to the implant abutments.
키워드
Dental implant;Focal adhesion;Cell-matrix adhsion
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